Cognitive and brain reserve have been implicated in the etiology of dementia. In this manuscript, we consider the relative contributions of early-life and late-life metrics for cognitive and brain reserve in the incidence of dementia.
Gyrification is a core feature of the cerebral cortex and has been associated with function and disease. In this manuscript, we show how gyrification changes throughout adulthood, and how it relates to cognitive function.
The genetic causes of late-life neurodegenerative diseases have been unearthed in recent years. In this manuscript, we consider whether such genetic burden also affects early-life processes like brain structure and cognitive function.